Pyridines and derivatives
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- (22)
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- (309)
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- (1)
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- (51)
- (2)
- (303)
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- (8)
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- (875)
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- (19)
- (357)
- (2)
- (4)
- (2)
- (1)
- (1)
- (5)
- (303)
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- (1,713)
- (2)
- (29)
- (7)
- (1)
- (92)
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- (15)
- (86)
- (128)
- (55)
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- (63)
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- (39)
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- (11)
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Filtered Search Results
Apexbio Technology LLC Tonabersat 175013-84-0 50mg
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Tonabersat (CAS 175013-84-0) is a gap-junction modulator targeting neuronal and satellite glial cell communication within the trigeminal ganglion It is designed to modulate gap-junction pathways thereby regulating neurological signaling associated with migraine aura and epilepsy Tonabersat exerts its biological activity primarily through inhibition of gap-junction communication leading to decreased cortical spreading depression (CSD) a process implicated in migraine pathophysiology Based on these pharmacological properties Tonabersat holds research potential in the study of migraine and epilepsy
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Cayman Chemical 3keto Petromyzonol
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A synthetic intermediate useful for pharmaceutical synthesis.
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Medchemexpress LLC Thymol blue | 76-61-9 | 1 G
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Thymol blue is a reversible pH indicator that responds to the pH of the solution through structural changes of protonation and deprotonation. It is red under acidic conditions and blue under alkaline conditions. This indicator can be used for quantitative detection through absorption peak shifts and selectively responds to pH changes, transitioning from red to yellow at pH 1.2-2.8 and from yellow to blue at pH 8.0-9.6.
- Responds to pH of solution through structural changes of protonation and deprotonation.
- Red under acidic conditions and blue under alkaline conditions.
- Achieves quantitative detection through absorption peak shift (435 nm/596 nm).
- Selectively responds to pH changes: red to yellow at pH 1.2-2.8, yellow to blue at pH 8.0-9.6.
- Can be fixed in a silica gel matrix for in-situ pH measurement in marine environments.
- Useful for acid-base monitoring in the biomedical field.
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Medchemexpress LLC Isoprothiolane | 50512-35-1 | 99.9% | 1 ML
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Isoprothiolane is a blast fungicide that exhibits antifungal, anti-inflammatory, and insecticidal properties, primarily acting on fungi during the penetration and growth stages of infecting hyphae. It can also reduce serum phospholipid and total lipid concentrations, regulating lipid metabolism, and is utilized in fatty liver research.
- Suppresses *Nilaparvata lugens* and *Sogatella furcifera* populations
- Promotes cell proliferation and inhibits IL-1 and IL-6 production in bovine mammary epithelial cells
- Inhibits 14C-acetate incorporation into fatty acids and triglycerides
- Inhibits 14C-methionine incorporation into phospholipids
- Used as an insecticide, pesticide, and in research related to fatty liver
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Medchemexpress LLC Vinburnine | 4880-88-0 | 99.8% | 1 ML
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Vinburnine, also known as (-)-Eburnamonine or (-)-Vincamone, is a vinca alkaloid and a metabolite of vincamine. It acts as a vasodilator and an allosteric modulator of muscarinic receptors M1-M4. This compound has shown anti-amnesia effects in mouse models and promotes erythrocyte glycolysis, improving tissue oxygen delivery.
- Acts as a vasodilator
- Metabolite of vincamine
- Allosteric modulator of muscarinic receptors M1-M4
- Decelerates binding of [H]N-methylscopolamine to muscarinic M1-M4 receptors
- Shows anti-amnesia effect in mouse amnesia models
- Promotes erythrocyte glycolysis
- Increases erythrocyte ATP and 2,3-diphosphoglycerol content
- Improves erythrocyte deformability and tissue oxygen delivery
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Medchemexpress LLC Vasculotide | 1359657-45-6 | 99.8% | 14000 (average) | 1 MG
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Vasculotide is an angiopoietin-1 mimetic that acts as a Tie-2 activator, inducing Tie-2 phosphorylation. It has anti-inflammatory and anti-permeability effects. This product ameliorates endotoxin-induced endothelial barrier dysfunction, promotes angiogenesis in a mouse model of diabetic ulcer, protects mice from vascular leakage, reduces mortality in murine abdominal sepsis, decreases microvascular leakage, and improves microcirculatory perfusion in a rat model of hemorrhagic shock.
- Acts as a Tie-2 activator
- Induces Tie-2 phosphorylation
- Exhibits anti-inflammatory effects
- Exhibits anti-permeability effects
- Ameliorates endothelial barrier dysfunction
- Promotes angiogenesis
- Protects from vascular leakage
- Reduces mortality in abdominal sepsis
- Decreases microvascular leakage
- Improves microcirculatory perfusion
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![Medchemexpress LLC 2,5-cyclohexadien-1-one, 2,6-dichloro-4-[(4-hydroxyphenyl)imino]-, sodium salt (1:1) | 620-45-1 | 98.0% | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000410808-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 2,5-cyclohexadien-1-one, 2,6-dichloro-4-[(4-hydroxyphenyl)imino]-, sodium salt (1:1) | 620-45-1 | 98.0% | 100 MG
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DCIP sodium is a blue dye commonly used in various biochemical and biotechnological applications as an indicator of redox reactions. It possesses unique chemical properties that enable it to change color based on the oxidation state of the substance being tested. This reagent is frequently employed in enzyme assays, such as for measuring the activity of succinate dehydrogenase, and in protein quantification methods, including the Lowry assay. DCIP sodium also serves as a biochemical reagent for life science-related research.
- Blue dye
- Acts as an indicator of redox reactions
- Changes color based on the oxidation state of the tested substance
- Utilized in enzyme assays (e.g., succinate dehydrogenase activity measurement)
- Applied in protein quantification methods (e.g., Lowry assay)
- Suitable as a biochemical reagent for life science research
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![Medchemexpress LLC Saralasin ([Sar1,Ala8] Angiotensin II) | 34273-10-4 | MFCD00167510 | 99.5% | 912.05 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000426281.png-250.jpg)
Medchemexpress LLC Saralasin ([Sar1,Ala8] Angiotensin II) | 34273-10-4 | MFCD00167510 | 99.5% | 912.05 | 5 MG
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Saralasin, an octapeptide analog of angiotensin II, acts as a competitive angiotensin II receptor antagonist (Ki: 0.32 nM for 74% binding sites) and also exhibits partial agonist activity. It is used in research for renovascular hypertension and renin-dependent hypertension.
- Functions as a competitive angiotensin II receptor antagonist
- Exhibits partial agonist activity
- Inhibits cell growth in 3T3 and SV3T3 cells
- Restores I*to*, fast and I*K*, slow to control levels in myocytes
- Ameliorates oxidative stress and tissue injury in cerulein-induced pancreatitis
- Increases serum renin activity in normal, conscious rats
- Inhibits binding of FITC-Ang II to rat liver membrane preparation
- Reduces ovulation rate and prostaglandin E2 and 6-keto-prostaglandin F1α levels in vitro
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Medchemexpress LLC Thymoquinone | 490-91-5 | 1 ML
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Thymoquinone is an orally active natural product isolated from N. sativa. It down-regulates the VEGFR2-PI3K-Akt pathway and exhibits a wide range of beneficial activities, including antioxidant, anti-inflammatory, and anticancer effects. This compound is valuable for research into various conditions such as Alzheimer's disease, cancer, cardiovascular disease, infectious disease, and inflammation.
- Orally active natural product
- Isolated from N. sativa
- Down-regulates VEGFR2-PI3K-Akt pathway
- Exhibits antioxidant and anti-inflammatory properties
- Provides anticancer, antiviral, and antifungal activity
- Offers anticonvulsant and antiangiogenic effects
- Demonstrates hepatoprotective properties
- Suitable for studies on Alzheimer's disease, cancer, and cardiovascular disease
- Applicable for research into infectious disease and inflammation
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![Medchemexpress LLC 1-[2-(4-phenylphenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-pyridine | 188396-77-2 | MFCD30747895 | 96.3% | 407.47 g·mol⁻¹ | C26H24F3N | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000249112.png-250.jpg)
Medchemexpress LLC 1-[2-(4-phenylphenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-pyridine | 188396-77-2 | MFCD30747895 | 96.3% | 407.47 g·mol⁻¹ | C26H24F3N | 25 MG
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Paliroden is an orally bioactive, non-peptidic neurotrophic small molecule that activates synthesis of endogenous neurotrophic factors. It has been investigated for potential use in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease.
- Orally bioactive small molecule suitable for in vivo studies.
- Activates synthesis of endogenous neurotrophic factors.
- Non-peptidic structure improves oral stability.
- High supplied purity (about 96.3%).
- Available as a solid, off-white to light yellow powder.
- Provided in multiple package sizes, including 25 MG.
- Molecular weight 407.47 g·mol⁻¹; formula C26H24F3N.
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Apexbio Technology LLC PF-03084014 865773-15-5 10mM (in 1mL DMSO)
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PF-03084014 is a small-molecule inhibitor targeting -secretase It is designed to selectively inhibit -secretase activity thereby blocking the proteolytic cleavage of Notch receptors and regulating the Notch signaling pathway PF-03084014 exerts its biological activity primarily by preventing -secretase-mediated cleavage which inhibits the release of Notch intracellular domain (NICD) fragments and reduces Notch pathway signaling Based on these pharmacological properties PF-03084014 holds research potential in anticancer applications as evaluated in preclinical tumor models such as leukemia and pancreatic adenocarcinoma both as a single agent and in combination strategies
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Medchemexpress LLC Cyromazine (Standard) | 66215-27-8 | 99.7% | 50 MG
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Cyromazine (Standard) is an analytical standard of Cyromazine, intended for research and analytical applications. It is a triazine insect growth regulator, cyclopropyl derivative of melamine, used as an insecticide and an acaricide. It affects the nervous system of immature larval stages of certain insects and interferes with the Ecdysone signaling pathway.
- Analytical standard grade for qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
- Insect growth regulator.
- Cyclopropyl derivative of melamine.
- Affects the nervous system of immature larval stages of certain insects.
- Used as an insecticide and an acaricide.
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Medchemexpress LLC Balipodect | 1238697-26-1 | MFCD28385852 | ≥98.0% | 428.4 g/mol | C23H17FN6O2 | 50MG
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Balipodect (TAK-063) is a potent, selective, orally active phosphodiesterase 10A (PDE10A) inhibitor used in research to investigate PDE10A-mediated signaling and neuropsychiatric mechanisms. It demonstrates subnanomolar potency and high selectivity, and is supplied for research use only.
- Potent PDE10A inhibition with IC50 0.30 nM
- High selectivity (>15,000-fold) for reduced off-target activity
- Orally active small molecule suitable for in vivo and in vitro studies
- High purity (≥98.0%) for analytical and experimental consistency
- Defined chemical identity: C23H17FN6O2, MW 428.4 g/mol, CAS 1238697-26-1
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Medchemexpress LLC Quercetin 3-O-β-D-glucofuranoside | 21637-25-2 | 464.38 | 1 ML
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Quercetin 3-O-β-D-glucofuranoside is a compound found widely in plants and is classified as a flavonoid and flavonol. It acts as an effective antioxidant and has been shown to suppress eosinophilic inflammation. Studies suggest it can blunt the negative effects of hydrogen peroxide on certain cells and reduce eosinophil counts in experimental settings.
- It is an effective antioxidant.
- It functions as an eosinophilic inflammation suppressor.
- It has been observed to counteract oxidative-induced damage in RGC-5 cells.
- It lowers eosinophil counts in bronchoalveolar lavage fluid, blood, and lung parenchyma in animal models.
- It reduces neutrophil counts in blood and interleukin-5 levels in lung homogenate in experimental models.
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Medchemexpress LLC GSK805 | 1426802-50-7 | 98.0% | 1 ML
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GSK805 is an orally active and CNS penetrant RORγt inhibitor. It inhibits RORγ and Th17 cell differentiation, making it suitable for immunity research by inhibiting the function of Th17 cells.
- Orally active and CNS penetrant RORγt inhibitor
- Inhibits RORγt and Th17 cell differentiation
- Used for immunity research
- Demonstrates antiproliferative activity against CWR22R, LNCaP, and LNCaP C4-2B cells
- Inhibits IL-17 production during Th17 cell differentiation
- Improves EAE in mice
- Reduces IFN-γ-IL-17+ and IFN-γ+IL-17+ T cells in EAE mice
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